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Positions:
Demonstrator (1975-1980), Assistant
Lecturer (1981-1983) and Lecturer of Organic Chemistry
(1988-1998), Assistant Professor of Organic Chemistry
(1998-), Department of Chemistry, Faculty of Science at
Qena, South Valley University, Qena, Egypt.
Awards:
Ph.D. Scholarship, the Egyptian Government (1983-1987);
ORS Award , the British Government (1984-1987); a Royal
Society Fellowship to the School of Chemistry, the
University of Leeds, U.K. (June 1992-June 1993); and a
Postdoctoral Fellowship by the Ministerio de Educacion y
Ciencia to Departmento de Quimica Organica 1, Facultad
de Ciencias Quimicas, Universidad Coplutense de Madrid,
España (October 1993- September 1995).
Sabatical leave visit to Departmento de
Quimica Organica 1, Facultad de Ciencias Quimicas,
Universidad Complutense de Madrid, España (April 1997-April
1998) sponsored by the Ministerio de Educacion y
Ciencia. Research Fellowship
Sponsored by Profesor B. Alcaide at Universidad
Complutense de Madrid (July 1999- June 2001).
Activities:
- A visite the complutense
university, Madrid - Spain , July - September 2007.
Experience:
Teaching Undergraduate and Postgraduate Courses in
Organic Chemistry (Lectures and Practical classes).
Research experience in Heterocyclic Chemistry including
various analytical techniques and NMR spectroscopy.
Areas of Interest:
(i) Decarboxylation of
a-amino
acids as a decarboxylative route to 1,3-dipoles and
relevance to pyridoxal decarboxylase enzymes.
(ii) Facile
decarboxylation of
a-keto
acids. Generalization of Hammick reaction; and a novel
synthesis of thioamides and 1,3,4-thiadiazoles.
(iii) Nondecarboxylative
1,3-dipolar cycloaddition reactions, leading to the
synthesis of proline derivatives.
(iv) The
b-lactams
chemistry; the unusual Baeyer-Villiger rearrangement of
b-lactam
aldehydes and the synthesis of
monobactams and related derivatives which are suitable
blocks for
b-lactam
antibiotics.
(v)
Synthesis of enantiopure polycyclic
b-lactams
via intramolecular nitrone-alkene cycloaddition of
2-azetidinone-tethered alkenylaldehydes.
(vi)
The use of metal/amine catallised 1,3-dipolar
cycloaddition as a route to stereocontrolled synthesis
of optically pure highly functionalized pyrrolizidine
systems.
(vii)
Metal catallised hetero Diels-Alder cycloaddition as a
route to stereocontrolled synthesis of optically pure
highly functionalized indolizidine systems.
(viii) Catalytic
deprotection of tertiary allylamines by using Grubbs’
carbene.
(ix)
Oxidation of the pyrrolidines to the
corresponding pyrrolines by using Cerium Ammonium
Nitrate (CAN).
Referees:
1- Professror R. Grigg, School of Chemistry, Leeds
University, Leeds LS9 JT2, England.
2- Professor Dr. B. Alcaide, Departmento
de Quimica 1, Facultad de Ciencias
Quimicas, Universidad Complutense de
Madrid, Ciudad Universtaria S/N, Madrid-
28040.
3- Professor Dr. M. A. Mohamed,
Department of Chemistry, Faculty of Science at Qena,
South Valley University, Qena, Egypt.
LIST OF PUBLICATIONS:
1) Reaction of Quinoxaline
Derivatives with Nucleophilic Reagents.
Badr, M.Z.A.; El-Naggar, G.M.;
El-Sherief, H.A.H.; Addel-Rahman, A. E.; Aly, M.F.,
Bull. Chem. Soc. Jap.,
1983, 56, 326.
2) Decarboxylative Transamination. A
New Route to Spirocyclic and Bridghead-Nitrogen
Compounds. Relevance to
a-Amino
Acids Decarboxylases.
Aly,
M. F.; Grigg, R.;
Sridharan, V.; Thianpatanagul, S.,
J. Chem. Soc. Chem. Comm.,
1984, 182.
3) Ready Decarboxylation of Imines
of a-Keto
Acids Mechanism and Application to Thioamides Synthesis.
Aly, M. F. and Grigg, R.,
J. Chem. Soc. Chem. Comm.,
1985, 1532.
4) The Reaction of Secondary
a-Amino
Acids with Carbonyl Compounds. Properties of the
Intermediate Azomethine Ylides. Oxazolidine Formation
versus 1,4-Prototropy.
Aly, M. F.; Ardill, H;
Grigg, R.; Leong-Ling, S.; Rajviroongit, S.;
Surendrakumar, S.
Tetrahedron Lett.
1987, 28,
6077.
5) X=Y-ZH Systems as
Potential 1,3-Dipoles. Part 10. The Decarboxylative
Route to Azomethine Ylides. Background and Relevance to
Pyridoxal Decarboxylases.
Aly, M. F.; Grigg, R.;
Thianpatanagul, S.; Sridharan, V.,
J. Chem. Soc.,Perkin Trans.I,
1988, 949.
6) X=Y-ZH Systems as Potential
1,3-Dipoles. Part 20. Decarboxylation of
a-Imino
Acids. Mechanism and Application to Thioamide Synthesis.
Aly, M. F. and Grigg, R.,
Tetrahedron 1988,
44, 7271.
7) A Novel Decarboxylative Route to
1,3-Dipolar Cycloaddition.
Aly, M.F. and Grigg, R.,
3rd Ibn
Sina Symposium on Heterocyclic Chemistry, Aswan, Egypt,
January 28-31, 1991.
8) Reaction of
3-methyl-1-phenyl-2-pyrazoline-4,5-dione with active
methylenes.
Aly, M.F., Younes, M.I,
Atta, A.H, Metwally, S.A.M.,
3rd Ibn
Sina Symposium on Heterocyclic Chemistry, Aswan, Egypt,
January 28-31, 1991.
9) Azomethine Ylides from the
Reaction of
4-(Dicyanomethilene)-3-methyl-1-phenyl-2-pyrazoline-5-one
with
a-Amino Acids and Their
Esters.
Metwally, S. A. M.; Aly, M.
F.; Abd-Alla, M. A.; Atta, F. M.; Abdel-Monem, M.
E.,
Liebigs Ann. Chem.1991,
387.
10) Preparation and Reactions of
Pyrazolone Blue.
Aly, M.F.; Younes, M.I.;
Atta, A.H. and Metwally, S.A.,
Third Conference on Chemistry
and its Role in Development, Mansoura,
Egypt, April 27-29, 1994.
11) Addition and Cycloaddition
Reactions with Pyrazole Blue.
Aly, M.F.; Younes, M.I.;
Atta, A.H. and Metwally, S.A.,
Third Conference on Chemistry
and its Role in Development, Mansoura, Egypt, April
27-29, 1994.
12) X=Y-ZH Systems as Potential
1,3-Dipoles. Part 41. Azomethine Ylide Formation from
the Reactions of
a-Amino
Acids and Esters with Alloxan (Strecker Reaction) and
with 1-phenyl-3-methylpyrazoline-4,5-dione.
Aly, M. F.; El-Naggar, G.
M.; El-Emary, T. I.; Grigg, R.; Metwally, S. A. M.;
Sivagnanam, S.,
Tetrahedron 1994,50,
895.
13) Nondecarboxylative 1,3-Dipolar
Cycloaddition as Potential Route to Proline Derivatives.
Aly, M. F.; Younes, M.
I.; Metwally, S. A. M.,
Tetrahedron 1994,
50, 3159.
14) The Unusual Baeyer- Villiger
Rearrangement of
b-Lactam
Aldehydes: Totally Stereoselective Entry to cis-3-Substituted
4-Formyloxy-2-azetadinones.
Alcaide,
B.; Aly, M.F.; Sierra, M.A.,
Tetrahedron Letters 1995,
36, 3401.
15)
a-Keto
Acids as a Route to Proline Derivatives.
Aly, M.F.
Bull. Fac. Sci. Assuit
University, 1995, 24(2-B), 75.
C.A.,
Vol. 125, No. 19.
248382q p. 1214, 1996.
16) Stereoselective Entry to
3-Substituted-4-Formyloxy-2-Azetiinones by
Baeyer-Villiger Rearrangement of
b-Lactam
Aldehydes.
Alcaide,
B.; Aly, M.F.; Sierra, M.A.,
11th International
Conference on Organic Synthesis (ICOS-11),
Amsterdam, Holand, June 30- July 4, 1996.
17) The Stereoselective Synthesis
of 3-Substituted-4-formyl-2-azetidinones by the Unusual
Baeyer-Villiger Reaction of
b-Lactam
Aldehydes. Scope and Synthetic Limitations.
Alcaide,
B.; Aly, M.F.; Sierra, M.A,
J.Org.
Chem., 1996, 61,
8819.
18) Decarboxylation of
a-Imino
Acids. One Pot Synthesis of 1,3,4-Thiadiazoles.
Aly, M.F.,
The First International
Conference on Basic Sciences and Advanced Technology,
Assuit University, Assuit, Egypt, November 9-12,
1996.
19) The Use of Dimethylamine as
Reagent for Regiospecific-4 Epimerization of cis-3-Substituted-4-Formyl-2-Azetidinones.
Alcaide,
B.; Aly, M.F.; Rodriguez-Vicente, A.
Tetrahedron Letters 1998,
39, 5865.
20) New Trends in the Chemistry of
Azomethine Ylides.
Aly, M.F. Review Article,
Submitted to the High Supreme Committee for the
Promotion to the Assistant Professorship in Egypt,
1998.
21) Regio- and Stereospecific
Construction of Novel Fused Polycyclic
b-Lactams
via Intramolecular 1,3-Dipolar Cycloaddition of
2-Azetidinone-pridged Alkenylnitrones.
Alcaide, B.; Alonso, J.M.;
Aly, M.F. and Saez, E.
18th European
Colloquium on Heterocyclic chemistry . Rouen, France,
October 4th- 7th, 1998.
22) Rapid Entry to Enantiopure
Polycyclic
b-Lactams
via Intramolecular Nitrone-Alkene Cycloaddition of
2-Azetidinone-Tethered Alkenylaldehydes.
Alcaide,
B.; Alonso, J.M.; Aly, M.F.; Saez, E.; Martinez-Alcazar,
M.P.; Hernandez-Cano, F.
Tetrahedron Letters 1999,
40, 5391.
23) Reaction of
1-Acetyl-3-dicyanomethylene-1,3-dihydro-2H-indol-2-one
with Some Nucleophilic Reagents: Synthesis of Some Indol
and Quinoline Derivatives.
Aly, M.F.; Atta, A.H.; Younes, M.I.,
Heterocyclic Communications, 2000, 6,
249.
24) Base-Promoted Isomerization of
cis-4-Formyl-2-azetidinones: Chemoselective C4-Epimerization
vs Rearrangement to Cyclic Enaminones.
Alcaide,
B.; Aly, M.F.; Rodríguez, C.; Rodríguez-Vicente,
A.
J.Org.
Chem. 2000, 65,
3453.
25) 1,3-Dipolar Cycloaddition of
2-Azetidinone-Tethered Azomethine Ylides. Application to
the Rapid, Stereocontrolled Synthesis of Optically Pure
Highly Functionalized Pyrrolizidine Systems.
Alcaide,
B.; Almendros, P.; Alonso, J.M.; Aly, M.F.
J.
Chem. Soc. Chem. Comm.,
2000, 485.
26) Rapid, and Stereocontrolled
Synthesis of Racemic and Optically Pure Highly
Functionalised Pyrrolizidine Systems via Rearrangement
of 1,3-Dipolar Cycloadducts derived from
2-Azetidinone-tethered Azomethine Ylides.
Alcaide, B.; Almendros, P.; Alonso,
J.M.; Aly, M.F.
J. Org. Chem., 2001, 66, 1351.
27) Unusual Fused Tricyclic
2-Azetidinones: Stereocontrolled Synthesis of Rigid
Dipeptide Surrogates from
b-Lactam-Tethered
Imines via Sequential Cycloaddition/ Ring-Closing
Metathesis. Alcaide, B.;
Almendros, P.; Alonso, J.M.; Aly, M.F; Redondo,
M.C. Synlett, 2001, 773.
28)
Dual Behavior of 2-Azetidinones-Tethered Arylimines as
Azadienophiles or Azadienes. Application totheAsymmetric
Synthesis of Indolizidines-Type Systems,
Alcaide, B.; Almendros, P.; Alonso, J.M.;
Aly, M.F; Torres, M.R.Synlett, 2001,
1531.
29) A Novel Use of Grubbs’ Carbene.
Application to the Catalytic Deprotection to Tertiary
Allylamines.
Alcaide, B.; Almendros, P.; Alonso, J.M.;
Aly, M.F. Organic Letters, 2001,
3781.
30)
Efficient
Entry to Highly Functionalized
b-Lactams
by Regio- and Stereoselective 1,3-Dipolar Cycloaddition
Reaction of 2-Aetidinone-Tethered Nitrones. Synthetic
Applications.
Alcaide, B.; Almendros, P.; Alonso, J.M.;
Aly, M.F; Pardo, C.; Saez, E and Rosario Torres,
M. J. Org. Chem.,
2002, 67, 7004.
31)
Useful Dual
Diels-Alder behavior of 2-Aetidinone-Tethered Arylamines
as azadienophiles or Azadienes. A
b-Lactam-Based
Stereocontrolled Access to Optically Pure Highly
Functiolized Indolizidine Systems. Alcaide, B.;
Almendros, P.; Alonso, J.M. and Aly, M.F.Chemistry-A
European Journal, 2003, 9, 3415.
32) New
Methodology for the Synthesis of
3,7-Diazabicyclo[3.3.0]oct-3-enes by Using Cerium
Ammonium Nitrate.
Aly, M.F. The 7th
International Conference on Chemistry and Its Role in
Development, Faculty of Science, Mansoura University,
Egypt (14-17 April 2003).
32)
Convenient
and General Potential Route to cis-trans
b-Lactams
Isomerisation.
Aly, M.F.Bull.
Fac. Sci., Assiut Univ.,
2003, 32 (2-B), 25.
33)
Stereospeific
Non-Decarboxylative 1,3-Cycloaddition as a Potential
Route to Some Tricyclic Fused Systems.
Aly, M.F.; Tmeric, H.H. and Elghareeb,
A.E., Heterocycles, 2006, submitted. |
